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Detection of vancomycin resistance in Enterococcus faecium and Enterococcus faecalis via cell wall
Technology The technology reveals cell wall remodeling dynamics with the innovative design of peptide molecules that mimic the structures of enzymes that are directly involved in peptidoglycan biosynthesis and direct indicators of vancomycin resistance enterococcus (VRE). The primary mechanism of action for vancomycin is to prevent cell wall synthe...
Published: 2/21/2017   |   Inventor(s): Marcos Pires
Category(s): Biology, Chemical, Chemicals & Materials Science, Chemistry, Life Sciences
Acid-resistant, Thermally Stable Polysaccharide Lyase
SUMMARY A major concern in food production is to avoid contamination with pathogenic bacteria, which can occur at almost any stage of food processing. Common pathogenic bacteria of concern include Campylobacter species, Listeria monocytogenes, Salmonella enteritidis, Escherichia coli, and Vibrio parahaemolyticus. Various strategies have been explor...
Published: 8/3/2015   |   Inventor(s): Bryan Berger
Category(s): Biomaterials, Biology
Use of Unnatural D-amino Acids to Recruit Endogenous Antibodies as a Novel Antibacterial Therapy
SUMMARYLehigh University has developed an unnatural synthetic amino acid (D-dinitrophenyllysine) as a novel single-agent anti-bacterial (gram positive) agent. It has been recently discovered (2009) that almost every straing of bacteria tested (both gram positive and negative), including many that are pathogenic, will incorporate D-amino acids (unna...
Published: 5/19/2014   |   Inventor(s): Marcos Pires
Category(s): Biology, Chemistry
Facile Assay for the Cancer-Linked Peptidylarginine Deiminase
SUMMARYThe protein peptidylarginine deiminase (PAD) plays an important role in the life cycle of normal human cells, and the deregulation of PADs has been implicated in the development of many diseases. The ability to measure this in a facile manner could prove very useful in the development of drug therapies.  This technology was developed to meas...
Published: 4/16/2014   |   Inventor(s): Marcos Pires
Keywords(s): Fluorescence, Life Sciences, Lipoprotein Metabolism
Category(s): Life Sciences, Biology
Engineered, Thermally-Stable Alginate Lyase with High Activity and Broad Substrate Specificity Against Bacterial Exopolysaccharides
SUMMARY Lehigh University has developed an alignate lyase capable of degrading multiple types of exoploysaccharides (EPS) found in bacterial biofilms, which are correlated with increased drug resistance in several pathogens. This material has the ability to break down components from biofilms of different organisms and can be combined with other an...
Published: 11/6/2012   |   Inventor(s): Bryan Berger
Category(s): Life Sciences, Biology