Search Results - Life Sciences

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Detection of vancomycin resistance in Enterococcus faecium and Enterococcus faecalis via cell wall
Technology The technology reveals cell wall remodeling dynamics with the innovative design of peptide molecules that mimic the structures of enzymes that are directly involved in peptidoglycan biosynthesis and direct indicators of vancomycin resistance enterococcus (VRE). The primary mechanism of action for vancomycin is to prevent cell wall synthe...
Published: 2/21/2017   |   Inventor(s): Marcos Pires
Category(s): Biology, Chemical, Chemicals & Materials Science, Chemistry, Life Sciences
A Microfluidic Device with Microscale Wavy Pattern for Efficient Capturing of Circulating Tumor Cells
SUMMARYLehigh University has developed a wavy micropatterned microfluidic device for capturing circulating tumor cells from whole blood with high efficiency, selectivity and throughput. A capturing agent is immobilized on the substrate that can selectively capture circulating tumor cells while not interacting with other cells present in the whole b...
Published: 5/20/2014   |   Inventor(s): Yaling Liu, Shu Yang, Yi Liu
Keywords(s): Blood, Microfluidics
Category(s): Materials and Nanotechnology, Chemicals & Materials Science, Life Sciences
Fabrication of Nano-Macro Porous Glass with a Water Soluble Pore Former
SUMMARYLehigh University has developed a superior method for creating interconnected nano-macro porous glass. Most often glass is used as one monolithic solid. However, it becomes the material of choice for many other applications in tissue engineering, catalysis, virus separation, etc., if it is made with controlled porosity. For example in regene...
Published: 4/25/2014   |   Inventor(s): Himanshu Jain, Hassan Moawad
Category(s): Life Sciences, Materials and Nanotechnology
Facile Assay for the Cancer-Linked Peptidylarginine Deiminase
SUMMARYThe protein peptidylarginine deiminase (PAD) plays an important role in the life cycle of normal human cells, and the deregulation of PADs has been implicated in the development of many diseases. The ability to measure this in a facile manner could prove very useful in the development of drug therapies.  This technology was developed to meas...
Published: 4/16/2014   |   Inventor(s): Marcos Pires
Keywords(s): Fluorescence, Life Sciences, Lipoprotein Metabolism
Category(s): Life Sciences, Biology
High-Yield Secretion System for Biosurfactant Production
SUMMARY Interest and use of surfactants has grown over the past 10 years, mainly due to the emergence of applications in biofuels, oil recovery and bioremediation. This has created a push towards green, biodegradable surfactants. However, large-scale biosurfactant production is limited due do a lack of understanding of both the identity and mechani...
Published: 11/6/2012   |   Inventor(s): Bryan Berger
Keywords(s): Biocompatible, Biosurfactant, Detergents, Green Synthesis, Sustainable Biomanufacturing
Category(s): Energy and Environment, Life Sciences
Dielectrophoretic Tweezers for Massively Parallel Manipulation of Microscopic Objects Suspended in Liquid Medium
SUMMARY The whole genome sequencing is poised to become a new standard in the healthcare paradigm. The mainstream use of personal genome sequencing can only become a reality when a profile for e ach individual can be made in real time and at a low cost. Lehigh University has developed eielectrophoretic (DEP) tweezers to help overcome this issue. W...
Published: 11/6/2012   |   Inventor(s): Dmitri Vezenov, Peng Cheng, Michael Barrett, Piercen Oliver
Category(s): Life Sciences, Optical Networking and Sensors
Engineered, Thermally-Stable Alginate Lyase with High Activity and Broad Substrate Specificity Against Bacterial Exopolysaccharides
SUMMARY Lehigh University has developed an alignate lyase capable of degrading multiple types of exoploysaccharides (EPS) found in bacterial biofilms, which are correlated with increased drug resistance in several pathogens. This material has the ability to break down components from biofilms of different organisms and can be combined with other an...
Published: 11/6/2012   |   Inventor(s): Bryan Berger
Category(s): Life Sciences, Biology
Spatially Distributed Fourier Domain Optical Coherence Tomography
TechnologyOptical coherence tomography is a non-invasive imaging technology used for performing high-resolution cross-sectional imaging. Optical coherence tomography utilizes infrared light (in the range of approximately 800 to 1300 nm). The image produced from optical coherence tomography is constructed by measuring the echo time delay and wavelen...
Published: 10/25/2012   |   Inventor(s): Chao Zhou
Category(s): Life Sciences, Optical Networking and Sensors, Medical Imaging
Fabrication of Nanoporous Glass Fiber for Flexible Bioscaffolds and Other Biomedical Applications
SUMMARY As tissue engineering develops into the future of treatments requiring tissue replacement, new materials are needed to function as bioscaffolds. Lehigh University has pioneered methods for fabricating nano-macro porous bioactive glass for bone replacement. These materials are monolithic rigid structures suitable for many bone replacement co...
Published: 9/7/2012   |   Inventor(s): Himanshu Jain, Hassan Moawad
Category(s): Life Sciences, Materials and Nanotechnology
Hybrid Cancer Drug Delivery System with Regulated Activation and Drug Release by the Tumor
SUMMARY Lehigh University has developed a novel cancer drug delivery system with regulated activation and drug release triggered by the tumor microenvironment. This hybrid inorganic-peptide material exhibits high biocompatibility and stability and is capable of selective activation in the tumor microenvironment. This provides a system whose propert...
Published: 5/16/2012   |   Inventor(s): Bryan Berger, Mark Snyder
Category(s): Life Sciences
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