Circular Plasmonic Mach-Zehnder Interferometer


Lehigh University has developed a compact plasmonic Mach-Zehnder interferometer (MZI) integrated on a microfluidic chip for highly sensitive optical biosensing.


This technique combines nanoplasmonic architecture and sensitive interferometric techniques on a compact sensing platform for enhanced refractive index sensitivity. The inventors have demonstrated real-time, label-free, quantitative monitoring with high signal-to-noise ratio.


This technology is primarily applicable to mobile and remote uses. Lehigh Tech ID# 090811-01


This technology is protected by a United States Patent Application.


The worldwide market for biosensors was $6.72 billion in 2009, growing at an annual rate of over 11% until 2016, where it is estimated to reach $14.42 billion.[1] Applications for biosensors are growing, increasing demand and revenues for these technologies. [2] There is also a push in the market for miniaturized biosensor devices in order to integrate them into portable systems, providing a window of opportunity for new technologies entering the market with such an “on-chip” focus. [3]


[1] “Analytical Review of World Biosensors Market.” June 8, 2010. Frost and Sullivan web site (subscription required). (accessed September 21, 2010).

[2] “Strong Growth in Biosensors Market as Usage Increases Over a Range of Applications,” Research and Markets web site, (accessed February 11, 2010).

[3] John H.T. Luong, Keith B. Male, and Jeremy D. Glennon. “Biosensor technology: Technology push versus market pull.” Biotechnology Advances. Volume 26, Issue 5, September-October 2008. (accessed September 21, 2010).



Lehigh is interested in licensing this technology.  

App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Provisional [PR] United States 61/532,791 9/9/2011    
Patent Cooperation Treaty [PCT] United States PCT/US2012/053882 9/6/2012   7/8/2015
Utility United States 14/343,906 9,297,955 3/10/2014 3/29/2016 3/29/2036
For Information, Contact:
Rick Smith
Lehigh University
Filbert Bartoli
Qiaoqiang Gan